NMOSD or Devic disease is an autoimmune disorder of the CNS and identified by demyelination and damage of optic nerves and spinal cord and often mistaken with multiple sclerosis (MS). Specific anti-NMO antibodies in serum of patient to aquaporin-4 (AQP4) are diagnostic and complement system is cause of demyelination in NMOSD. NMOSD could be related to SLE, Sjogren’s syndrome, vasculitis or mixed connective tissue disease.
Panel Test:
● Autoantibodies:
o Aquaporin-4 Receptor Antibody (serum and CSF),
o Myelin Oligodendrocyte Glycoprotein (MOG) Antibody,
● CSF Analysis
o Cell Count, CSF
o Oligoclonal Band Profile
References
1. Jarius S, Aboul-Enein F, Waters P, et al. Antibody to aquaporin-4 in the long-term course of neuromyelitis optica. Brain 2008; 131:3072.
2. Sellner J, Boggild M, Clanet M, et al. EFNS guidelines on diagnosis and management of neuromyelitis optica. Eur J Neurol 2010; 17:1019.
3. Bennett JL, Lam C, Kalluri SR, et al. Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica. Ann Neurol 2009; 66:617.
4. Papadopoulos MC, Verkman AS. Aquaporin 4 and neuromyelitis optica. Lancet Neurol 2012; 11:535.
5. Hinson SR, McKeon A, Lennon VA. Neurological autoimmunity targeting aquaporin-4. Neuroscience 2010; 168:1009.
