NAIT is characterized by reduced platelet count less than 150000/µL following from maternal/fetal platelet antigens incompatible. Two mechanisms have been suggested to pathogenesis of NAIT. The first one mechanism is maternal exposure to human platelet antigen [HPA]-1a on fetal platelets lead to fetomaternal bleeding or on adult platelets due to previous platelet transfusions, the other on is maternal exposure to integrin-3 on placental cells within pregnancy.
Panel Test:
● Routine test:
o CBC with Platelet Count
o Platelet Antibodies, Indirect
o Platelet Antigen Genotyping
● Genetics test:
o HPA genes GP1BA, ITGA2B, ITGB3, ITGA2, ITGB3, and CD109
References
1. Curtis BR. Recent progress in understanding the pathogenesis of fetal and neonatal alloimmune thrombocytopenia. Br J Haematol 2015; 171:671.
