Peripheral blood eosinophilia can be caused allergic, infectious, inflammatory and neoplastic disorders. Although complications of eosinophilia are more common in patients with higher eosinophil counts (eg, >1500 eosinophils/microL), a patient with mild peripheral blood eosinophilia may have significant organ involvement by eosinophils. Thus, it’s important to think about the clinical status of the patient and to detect whether there is evidence of end-organ involvement.
Panel test:
o CBC and Automated Differential
o Blood Smear Interpretation
o Eosinophil Granule Major Basic Protein (Tissue)
o Strongyloides Antibody, IgG
o Leukemia/Lymphoma immunophenotyping
o T-Cell Clonality (Analysis of TCR V-Beta)
o Immunobullous Disease autoantibodies
References
1. Roufosse F, Weller PF. Practical approach to the patient with hypereosinophilia. J Allergy Clin Immunol 2010; 126:39.
2. Chen YY, Khoury P, Ware JM, et al. Marked and persistent eosinophilia in the absence of clinical manifestations. J Allergy Clin Immunol 2014; 133:1195.
