Vitiligo

Vitiligo is an approximately common acquired disorder of patchy pigmentary loss characterized by the development of well-defined white macules on the skin, often start in childhood or early adult. Biopsies of lesional skin reveal an inflammatory destruction of melanocytes.

References:

1. Whitton M, Pinart M, Batchelor JM, et al. Evidence-based management of vitiligo: summary of a Cochrane systematic review. Br J Dermatol 2016; 174:962.
2. Ezzedine K, Eleftheriadou V, Whitton M, van Geel N. Vitiligo. Lancet 2015; 386:74.