Sjögren’s syndrome (SS), a complex autoimmune rheumatic disease that specifically targets salivary and lachrymal glands, could be a disorder of immune system. It is identified by its two most typical symptoms — dry eyes and a xerostomia. The condition often accompanies other immune system disorders, like rheumatoid arthritis and lupus. In Sjogren’s syndrome, the mucous membranes and moisture-secreting glands of eyes and mouth are affected first — cause decreased tears and saliva. Although Sjogren’s syndrome will develop at any age, most of the people are older than 40 at the time of diagnosis. The condition is far more common in women. Treatment focuses on relieving symptoms.
Panel test:
Immunologic tests:
Antinuclear antibody (ANA):
Extractable Nuclear Antibody Tests
- The anti-SSA
- anti-SSB
- Rheumatoid factor (RF).
- levels of immunoglobulin.
- Novel Autoantibodies:
- anti-salivary gland protein 1 SP-1
- anti-carbonic anhydrase 6 CA-6
- anti-parotid secretory protein PSP
b2-MG
Cryoglobulins
References:
- Mariette X, Criswell LA. Primary Sjögren’s Syndrome.N Engl J Med. 2018; 378(10): 931-939. PubMed
- Beckman KA, Luchs J, Milner MS. Making the diagnosis of Sjögren’s syndrome in patients with dry eye.Clin Ophthalmol. 2016; 10: 43-53. PubMed
