Psoriasis is a chronic inflammatory skin disease that identified by scaly plaques resulted by hyperproliferation of keratinocytes. Most patients are not serious enough to affect general health and are treated in the outpatient setting. Psoriasis patients were shown infiltration of CD4 and CD8 positive T cell, increasing cytokine production by keratinocytes and stimulating Th17 cells.
Panel test:
There is not diagnostic test for definite diagnosis of psoriasis.
Nine gene loci (PSOR1-9) is associated with psoriasis
• HLA-Cw6 associated with early onset disease.
• shared genes with Crohn’s disease (increased incidence of Crohn’s disease in psoriasis).
