Pemphigus foliaceus is and autoimmune blistering disorder in which cleavages in the superficial epidemis result in cutaneous erosions. Pemphigus foliaceus mostly occurs in middle-aged individuals, affecting both sex in equal numbers. Pemphigus foliaceus is generated by IgG autoantibody against desmoglein 1 (Dsg1), a transmembrane glycoprotein cadherin important to cell–cell adhesion and signaling between keratinocytes.
Panel test:
· Immunogenetics:
o Increased incidence of HLA-DQ1, DR4; DR7 may confer resistance.
· Autoantibodies
o anti desmoglein-1 (a cadherin) antibody.
o anti Desmoglein-3 antibody (Dsg-3)
References
- Mihai S, Sitaru C. Immunopathology and molecular diagnosis of autoimmune bullous diseases. J Cell Mol Med 2007; 11:462.
- Sitaru C, Zillikens D. Mechanisms of blister induction by autoantibodies. Exp Dermatol 2005; 14:861.
- James KA, Culton DA, Diaz LA. Diagnosis and clinical features of pemphigus foliaceus. Dermatol Clin 2011; 29:405.
