· Insulinoma
Insulinomas are the most common functional pancreatic neuroendocrine tumors (PNETs). They result from growth of islet cells that produce excess insulin. Insulinomas may be associated with multiple endocrine neoplasia 1 (MEN1) or Wermer syndrome. Only 10% of insulinomas are malignant.
Panel test:
· Proinsulin, Intact/ Insulin Ratio
· C-Peptide (serum, plasma)
References
Guidelines
1. Oberg K, Couvelard A, Fave GD, Gross D, Grossman A, Jensen RT, Pape U, Perren A, Rindi G, Ruszniewski P, Scoazec J, Welin S, Wiedenmann B, Ferone D, all other Antibes Consensus Conference participants. ENETS Consensus Guidelines for Standard of Care in Neuroendocrine Tumours: Biochemical Markers. Neuroendocrinology. 2017; PubMed
2. Perren A, Couvelard A, Scoazec J, Costa F, Borbath I, Fave GD, Gorbounova V, Gross D, Grossma A, Jense RT, Kulke M, Oeberg K, Rindi G, Sorbye H, Welin S, Antibes Consensus Conference participants. ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Pathology: Diagnosis and Prognostic Stratification.Neuroendocrinology. 2017; 105(3): 196-200. PubMed
3.
4. NCCN Clinical Practice Guidelines in Oncology, Neuroendocrine and Adrenal Tumors. Version 2.2018. NCCN Clinical Practice Guidelines in Oncology, Neuroendocrine and Adrenal Tumors. Version 2.2018.. Fort Washington, PA [Updated: May 2018; Accessed: May 2018]
5. Falconi M, Eriksson B, Kaltsas G, Bartsch DK, Capdevila J, Caplin M, Kos-Kudla B, Kwekkeboom D, Rindi G, Klöppel G, Reed N, Kianmanesh R, Jensen RT, Vienna Consensus Conference participants. ENETS Consensus Guidelines Update for the Management of Patients with Functional Pancreatic Neuroendocrine Tumors and Non-Functional Pancreatic Neuroendocrine Tumors. Neuroendocrinology. 2016; 103(2): 153-71. PubMed
6. Pancreatic Neuroendocrine Tumors (Islet Cell Tumors) Treatment (PDQ) – Health Professional Version. National Cancer Institute. [Updated: Feb 2018; Accessed: Aug 2018]
7. O’Toole D, Kianmanesh R, Caplin M. ENETS 2016 Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Tumors: An Update. Neuroendocrinology. 2016; 103(2): 117-8. PubMed
