آزمایشگاه ملل شهرک سلامت اصفهان
FA

Gastrointestinal Stromal Tumors (GISTs)

فهرست

Gastrointestinal stromal tumor (GIST) is a potentially malignant tumor and the most frequent type of sarcoma in the gastrointestinal tract. They are usually found in stomach (60%), small intestine, jejunum and ileum (30%), duodenum (5%), rectum (2–3%) and colon (1–2%).

Panel test:

● CD117
● DOG1
● BRAF
● SDHB
● CD34
● Caldesmon
● Smooth Muscle Actin (SMA)
● Desmin
● S-100
● Glial Fibrillary Acidic protein (GFAP)
● Beta-catenin-1

References

Guidelines
1. ESMO/European Sarcoma Network Working Group. Gastrointestinal stromal tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.Ann Oncol. 2014; 25 Suppl 3: iii21-6. PubMed
2. NCCN Clinical Practice Guidelines in Oncology, Soft Tissue Sarcomas, Version 2.2018. National Comprehensive Cancer Network. Fort Washington, PA [Updated: Mar 2018; Accessed: Nov 2018]
3. Hampel H, Bennett RL, Buchanan A, Pearlman R, Wiesner GL, Guideline Development Group, American College of Medical Genetics and Genomics Professional Practice and Guidelines Committee and National Society of Genetic Counselors Practice Guidelines Committee. A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors: referral indications for cancer predisposition assessment. Genet Med. 2015; 17(1): 70-87. PubMed

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