Chronic Lymphocytic Leukemia (CLL)

Chronic lymphocytic leukemia (CLL) is characterized by the progressive accumulation of usually monoclonal, functionally incompetent lymphocytes. Patients with CLL commonly develop complications associated with the intrinsic immune dysfunction that results in immunodeficiency and the development of autoimmune disorders.

Panel tests:

Flow cytometry panel:

Leukemia/Lymphoma Phenotyping Evaluation by Flow Cytometry

Aid in evaluation of hematopoietic neoplasms (ie, leukemia, lymphoma)

B-CLL Panel is CD5, CD19, CD10, CD20, CD23, CD200, FMC7.

References:

1. Tsiodras S, Samonis G, Keating MJ, Kontoyiannis DP. Infection and immunity in chronic lymphocytic leukemia. Mayo Clin Proc 2000; 75:1039.

Perkins JG, Flynn JM, Howard RS, Byrd JC. Frequency and type of serious infections in fludarabine-refractory B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma: implications for clinical trials in this patient population. Cancer 2002; 94:2033.