Goodpasture syndrome is a rare serious disease in which immune system attacks the kidneys and lungs mistakenly. First onset is sudden and may be like flu symptoms and arthralgia. This disease is related to other autoimmne disease such as wegner’s granulomatosis, thyroid disease, Bhecet’s disease, celiac disease, IBD, lymphoma, thymoma and other malignancies.
Panel Test:
● Routine tests:
o CBC with Automated Differential
o BUN and Creatinine
o Urine analysis for casts
o CRP and ESR
● Immunopathology:
o Anti-GBM antibodies
o Type IV collagen
o Deposition of C3 (linear staining)
● Immunogenetics:
o It’s strongly associated with DRw15(DR2)/DQw6, DR4/DQw7
● Autoantibodies:
o Anti-GBM antibodies: About 90% of patients are positive and it can help for monitoring of therapy
o ANCA: for screening vasculitis
References
1. Olson SW, Arbogast CB, Baker TP, et al. Asymptomatic autoantibodies associate with future anti-glomerular basement membrane disease. J Am Soc Nephrol 2011; 22:1946.
2. Canney M, O’Hara PV, McEvoy CM, et al. Spatial and Temporal Clustering of Anti-Glomerular Basement Membrane Disease. Clin J Am Soc Nephrol 2016; 11:1392.
3. Pusey CD. Anti-glomerular basement membrane disease. Kidney Int 2003; 64:1535.
