Acute Lymphoblastic Leukemia (ALL)

Acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL) is the most common childhood malignancy. Leukemia and lymphoma are overlapping clinical presentations of the same disease. Diagnosis and classification do not distinguish between these entities and they should be referred to collectively as ALL/LBL [1]. ALL/LBL comprises B-lineage, T-lineage, and uncommon variants (ie, NK-lineage, early T progenitor ALL [a provisional diagnostic category]).

Panel Tests:

Immunophenotyping Flow Cytometry

CD19, CD20, CD22, CD4, CD8, CD3, CD2, CD7, CD34, CD10, CD1a, CD45, TCR γ-δ, cytoplasmic CD3, TdT.

B-Cell Acute Lymphocytic Leukemia (B-ALL) Minimum Residual Disease Detection by Flow Cytometry Detect

References:

1. Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 2016; 127:2391.
2. Pui CH, Relling MV, Downing JR. Acute lymphoblastic leukemia. N Engl J Med 2004; 350:1535.