Definition
Primary and metastatic brain tumors are a heterogeneous group of neoplasms with varied outcomes and management strategies. Primary brain tumors range from pilocytic astrocytomas, which are very uncommon, noninvasive, and surgically curable, to glioblastoma multiforme, the most common intraparenchymal brain tumor in adults, which is highly invasive and virtually incurable.
CNS tumors are associated with a range of symptoms and complications, such as edema, seizures, endocrinopathy, fatigue, psychiatric disorders, and venous thromboembolism, that can seriously impact quality of life.
Lab tests
- ATRX
- IDH1 R132H
- Ki-67 with Interpretation
- Glial Fibrillary Acidic Protein (GFAP)
- S-100 Protein
- CD56 (NCAM)
- p53 with Interpretation
- CD117 (c-Kit)
- Placental Alkaline Phosphatase (PLAP)
- Human Chorionic Gonadotropin (Beta-hCG)
- Alpha-1-Fetoprotein (AFP)
- Inhibin
- D2-40
- Synaptophysin
References
Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016; 131(6): 803-20. PubMed
