The immune-mediated neuropathies are a mainly group of neuropathies that often lead to severe neurologic dysfunction. Autoimmune neuropathies present with a broad range of symptom but main signs are including tingling in the feet or hands, burning, stabbing pain in affected regions, loss of balance and coordination, muscle weakness in the feet.
The overlap of symptoms among syndromes often makes diagnosis difficult. Autoimmune neuropathies can also happen as paraneoplastic disorders in the setting of cancer.
Panel Test:
● Motor and Sensory Neuropathy Evaluation
o Purkinje cell/neuronal nuclear IgG
o neuronal nuclear (Hu, Ri, and Yo) IgG
o neuronal nuclear antibody (ANNA) IgG titer
o MAG IgM
o SGPG Igasialo-GM1, GM1, GD1a, GD1b IgG and IgM
o GQ1b abs
o SPEP (Serum protein electrophoresis); immunoglobulins A, G, and M
● Paraneoplastic antibodies:
o ANNA-1 (Hu)
o ANNA-2 (Ri)
o PCCA-1 (Yo),
o amphiphysin,
o CV2.1 antibody.
References:
1. Chaudhry HM, Mauermann ML, Rajkumar V. Monoclonal Gammopathy-Associated Peripheral Neuropathy: Diagnosis and Management. Mayo Clin Proc. 2017; 92(5): 838-850. PubMed
