§ Acquired aplastic anemia
Acquired AA, characterized by pancytopenia and hypocellular bone marrow in the absence of abnormal infiltrates and without increased reticulin, accounts for most cases of AA in children and young adults. The peripheral blood typically exhibits pancytopenia, reticulocytopenia, and normocytic or macrocytic erythrocytes. Patients with AA have an increased risk of developing paroxysmal nocturnal hemoglobinuria (PNH), myelodysplastic syndrome (MDS), or acute leukemia.
Lab tests:
CBC and Automated Differential
Blood Smear with Interpretation
Liver function test
Viral hepatitis studies
LDH
Serum bilirubin
Serum B12 vitamin
Erythrocyte folate level
Fibrinogen
Bone marrow aspiration and biopsy
diepoxybutane (DEB) screening for Fanconi anemia Telomere length measurements for Dyskeratosis congenital
HLA-typing (HLA-DRB1*15)
- oung NS, Bacigalupo A, Marsh JC. Aplastic anemia: pathophysiology and treatment. Biol Blood Marrow Transplant 2010; 16:S119.
- Guinan EC. Acquired aplastic anemia in childhood. Hematol Oncol Clin North Am 2009; 23:171.
- Young NS, Maciejewski J. The pathophysiology of acquired aplastic anemia. N Engl J Med 1997; 336:1365.
