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Systemic Vasculitis

Systemic Vasculitis

Vasculitis is a sort of rare inflammatory disorders and immune-mediated in blood vessels.  Vasculitis can lead to reduced blood flow to tissues like nerves, skin and lungs. These changes can result serious damage in the critical organs. Vasculitis is often serious disease and it can be sometimes fatal. Vasculitis is a systemic disease so, patients have fever, weight loss, fatigue and pain. 

Panel Test:

  • ANCA- (antineutrophil cytoplasmic antibody)
  • MPO antibodies, IgG;
  • serine PR3, IgG
  • CBC and Automated Differential
  • Renal Function tests:
    • albumin,
    • calcium,
    • carbon dioxide,
    • creatinine,
    • chloride,
    • glucose,
    • phosphorous,
    • potassium,
    • sodium,
    • blood urea nitrogen (BUN),
    • Urinalysis, Complete
    • Hepatic Function:
  • bilirubin, direct; bilirubin, total; 
  • alkaline phosphatase; aspartate aminotransferase; alanine aminotransferase;
  • protein, total; 
  • albumin (serum or plasma)
  • CRP and ESR
  • Cryoglobulin,
  • Glomerular Basement Membrane Antibody, IgG
  • Prothrombin Time
  • Rickettsia rickettsii (Rocky Mountain Spotted Fever) Antibodies, IgG & IgM
  • Hepatitis tests:
  • hepatitis A virus (HAV) IgM,
  • hepatitis B virus (HBV) core antibody IgM,
  • HBV surface antigen,
  • hepatitis C virus (HCV) antibody
    • Human Immunodeficiency Virus (HIV) C
    • Rapid Plasma Reagin (RPR)
  • Varicella-Zoster Virus Antibodies, IgG and IgM
  • Antinuclear Antibody (ANA) with HEp-2 Substrate
  • Double-Stranded DNA (dsDNA) Antibody, IgG by
  • Extractable Nuclear Antigen Antibodies (Smith/RNP, Smith, SSA 52, SSA 60, and SSB)
  • Rheumatoid Arthritis Panel
  • Beta-2 Glycoprotein 1 Antibodies, IgG and IgM
  • Cardiolipin Antibodies, IgG and IgM
  • Blood Smear with Interpretation
  • Angiotensin Converting Enzyme, Serum

References

  1. Jennette JC, Falk RJ, Bacon PA, et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum 2013; 65:1.
  2. American Society of Clinical Pathologists (ASCP): Addendum to the international consensus statement on testing and reporting of antineutrophil cytoplasmic antibodies − Quality control guidelines, comments, and recommendations for testing in other autoimmune diseases (2003)

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