PAN is an idiopathic systemic vasculitis identified by necrotizing lesions in involved organs such as kidneys, muscles, joints, nerves, skin and gastrointestinal track. PAN is classified in to subacute, acute and chronic stages. It’s a similar to many diseases like Hepatitis B and C infections, Churg-strauss syndrome, cogan’s syndrome and kawaski disease.
Panel Test:
● CBC with Automated Differential
● Urinalysis,
● C-Reactive Protein and ESR
● MPO/PR3 Antibodies
● Hepatitis Virus tests:
o hepatitis A virus (HAV) IgM,
o hepatitis B virus (HBV) core antibody IgM,
o HBV surface antigen (HBsAg), and
o hepatitis C virus (HCV) antibody;
● Antinuclear Antibodies (ANA), IgG
● Glomerular Basement Membrane Antibody, IgG
References
1. Jennette JC, Falk RJ, Bacon PA, et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum 2013; 65:1.
2. Ribi C, Cohen P, Pagnoux C, et al. Treatment of polyarteritis nodosa and microscopic polyangiitis without poor-prognosis factors: A prospective randomized study of one hundred twenty-four patients. Arthritis Rheum 2010; 62:1186.
3. Puéchal X, Pagnoux C, Baron G, et al. Adding Azathioprine to Remission-Induction Glucocorticoids for Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss), Microscopic Polyangiitis, or Polyarteritis Nodosa Without Poor Prognosis Factors: A Randomized, Controlled Trial. Arthritis Rheumatol 2017; 69:2175.
