It’s a the most common form of systemic vasculitis which affects capillaries in the kidney and skin. In HSP deposition of immunoglobulin A (IgA1) and C3 (complement) demonstrate on the vein walls. The renal injury could be mediated by IgA and IgG autoantibodies against mesangial cell antigens. IgAV occurs often in children more than in adults but involvement in kidney is more occur and more severe in older adults.
Panel Test:
● CBC with Automated Differential
● BUN and Creatinine
● Urine analysis for casts
● CRP and ESR
● ANCA or Anti-Neutrophil Cytoplasmic Antibody
● Immunoglobulin A
References
1. Jennette JC, Falk RJ, Bacon PA, et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum 2013; 65:1.
2. Piram M, Mahr A. Epidemiology of immunoglobulin A vasculitis (Henoch-Schönlein): current state of knowledge. Curr Opin Rheumatol 2013; 25:171.
3. Bonetto C, Trotta F, Felicetti P, et al. Vasculitis as an adverse event following immunization – Systematic literature review. Vaccine 2016; 34:6641.
4. Woerner A, Rudin C, Bonetto C, et al. IgA vasculitis (Henoch-Schönlein): Case definition andguidelines for data collection, analysis, and presentation of immunisation safety data. Vaccine 2017; 35:1559.
