The idiopathic inflammatory myopathies are a diverse group of connective tissue diseases of unknown etiology characterized by chronic inflammation of skeletal muscle, or myositis. The most common types of those disorders are consisted of dermatomyositis (DM), polymyositis (PM), necrotizing myopathy (NM) or immune mediated necrotizing myopathy, and sporadic inclusion body myositis (sIBM). Patients ordinarily present with sub-acute to chronic onset of proximal weakness revealed by difficulty with getting up from a chair, climbing stairs, pick up objects, and brushing hair.
Panel test:
• Creatine kinase (CK)
Aldolase, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LD), serum myoglobin
• Thyroid-stimulating hormone
• Antinuclear antibodies Antibody
• Antisynthetase antibodies
anti-Jo-1
anti-PL-7
anti-PL-12
anti-EJ
anti-OJ
· Other myositis-specific antibodies
Anti SRP
Anti Mi-2
Anti P155/140
Anti NXP-2 (nuclear matrix protein-2)
Anti TIF1-gamma (TIF1-y)
Anti MDA5 (CADM-140)
Anti SAE1 (SUMO activating enzyme)
Anti HMGCR
Anti Mup44
• Myositis- Associated antibodies- Target autoantigen and overlap syndromes-
anti-PM/Scl-100
anti-SSA(RO)
anti-U1 RNP
Ku
References
- Choosing Wisely. An initiative of the ABIM Foundation. [Accessed: Apr 2019]
- Dalakas MC. Inflammatory muscle diseases. N Engl J Med 2015; 372:1734.
- O’Connell MJ, Powell T, Brennan D, et al. Whole-body MR imaging in the diagnosis of polymyositis. AJR Am J Roentgenol 2002; 179:967.
- Lundberg IE. Idiopathic inflammatory myopathies: why do the muscles become weak? Curr Opin Rheumatol 2001; 13:457.
- Amato AA, Barohn RJ. Evaluation and treatment of inflammatory myopathies. J Neurol Neurosurg Psychiatry 2009; 80:1060.
- Distad BJ, Amato AA, Weiss MD. Inflammatory myopathies. Curr Treat Options Neurol 2011; 13:119
