Behcet disease is an inflammatory disorder that result wide inflammation of veins and arteries (vasculitis) especially small blood vessels in geneital, mouth, skin and eyes. The main clinical manifestation in patients is recurrent painful ulcers in genital track, sores and aphthous in gastrointestinal tracks (more in the tonsils, throat, lips, tongue and the roof of the mouth), skin lesions or artheritis. Inflammation of the eyes (uveitis) is detected in most of patients especially in younger people.
Panel Test:
There are not definit test for diagnosis. Diagnosis is based on clinical signs.
● CBC and Automated Differential
● CRP and ESR
● C9 level in serum: It’s often increased.
● vWF (von Willebrand factor: the level of vWF is increasing
● cryoglobulin
● Anti-cardiolipin antibody
● ANCA or Anti-Neutrophil Cytoplasmic Antibody
● MPO/PR3 Antibodies
References
1. EULAR/EUVAS: Recommendations for the management of Behçet disease (2008).
2. Mahr A, Belarbi L, Wechsler B, et al. Population-based prevalence study of Behçet’s disease: differences by ethnic origin and low variation by age at immigration. Arthritis Rheum 2008; 58:3951.
3. Dilek K, Ozçimen AA, Saricaoğlu H, et al. Cytokine gene polymorphisms in Behçet’s disease and their association with clinical and laboratory findings. Clin Exp Rheumatol 2009; 27:S73.
4. Mahr A, Belarbi L, Wechsler B, et al. Population-based prevalence study of Behçet’s disease: differences by ethnic origin and low variation by age at immigration. Arthritis Rheum 2008; 58:3951.
5. Yazici H, Seyahi E, Yurdakul S. Behçet’s syndrome is not so rare: why do we need to know? Arthritis Rheum 2008; 58:3640.
6. Calamia KT, Wilson FC, Icen M, et al. Epidemiology and clinical characteristics of Behçet’s disease in the US: a population-based study. Arthritis Rheum 2009; 61:600.
7. Mahr A, Maldini C. [Epidemiology of Behçet’s disease]. Rev Med Interne 2014; 35:81.
