Paraneoplastic neurologic syndromes (PNS) comprise an extensive group of heterogeneous disorders that can affect any part of the central and peripheral nervous system. There is evidence that many of these disorders are mediated by immunologic responses triggered by the presence of a cancer.
Lab tests
• Purkinje cell/neuronal nuclear IgG screen
• Neuronal nuclear antibody (ANNA) IgG
• Purkinje cell antibody, titer
• Neuronal nuclear antibodies (Hu, Ri, Yo) IgG
• Amphiphysin
Reference
Zuliani L, Graus F, Giometto B, Bien C, Vincent A. Central nervous system neuronal surface antibody associated syndromes: review and guidelines for recognition. J Neurol Neurosurg Psychiatry. 2012; 83(6): 638-45. PubMed