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Paraneoplastic Neurological Syndromes and Associated Disorders – PNS

Paraneoplastic Neurological Syndromes and Associated Disorders – PNS
Paraneoplastic neurologic syndromes (PNS) comprise an extensive group of heterogeneous disorders that can affect any part of the central and peripheral nervous system. There is evidence that many of these disorders are mediated by immunologic responses triggered by the presence of a cancer.
 

Lab tests

• Purkinje cell/neuronal nuclear IgG screen
• Neuronal nuclear antibody (ANNA) IgG
• Purkinje cell antibody, titer 
• Neuronal nuclear antibodies (Hu, Ri, Yo) IgG 
• Amphiphysin 

Reference

Zuliani L, Graus F, Giometto B, Bien C, Vincent A. Central nervous system neuronal surface antibody associated syndromes: review and guidelines for recognition. J Neurol Neurosurg Psychiatry. 2012; 83(6): 638-45. PubMed

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