Hyperinsulinemic hypoglycemia (HH) is biochemically characterized by the unregulated secretion of insulin from the pancreatic β-cells in the presence of low blood glucose levels. HH is a major cause of brain injury and mental retardation in children. Postprandial hyperinsulinemic hypoglycemia in adults can be cause by noninsulinoma pancreatogenous hypoglycemia syndrome, gastric bypass surgery for morbid obesity, or mutations in the insulin receptor gene(6, 7).
Insulin antibodies
- Presence suggests administration of insulin, rather than endogenous insulin such as that secreted by insulinoma
References
- Pickartz T, Mayerle J, Lerch MM. Autoimmune pancreatitis. Nature Clinical Practice Gastroenterology &Amp; Hepatology. 2007;4:314.
- Fan B-G, Andrén-Sandberg A. Autoimmune pancreatitis. N Am J Med Sci. 2009;1(4):148-51.
- Nessa A, Rahman SA, Hussain K. Hyperinsulinemic Hypoglycemia – The Molecular Mechanisms. Front Endocrinol (Lausanne). 2016;7:29-.
- Kapoor RR, James C, Hussain K. Advances in the diagnosis and management of hyperinsulinemic hypoglycemia. Nature Clinical Practice Endocrinology &Amp; Metabolism. 2009;5:101.
